Alister was best friends with Kaden and as children they had many adventures together in the Breegus System, notably hoverbooting on Krell Canyon. As they grew older Kaden had a son and presumably joined Alister in the Center for Advanced Lombax Research and Lombax Praetorian Guard.
Later, the Lombaxes were approached by an inventor who, unknown to them, was Percival Tachyon. He possessed ideas for technology considerably more advanced than what they were using at the time. Despite warnings from Kaden to do otherwise, Azimuth helped the inventor by giving him access to Lombax technology, believing it could repair the galaxy from the Great War. Tachyon instead would use this technology to crush Fastoon and build his new empire. The General held himself responsible for the attack as well as the deaths of Kaden and hundreds of Lombaxes. When the Lombaxes escaped, Azimuth was forbidden from joining them and was exiled. He would eventually find himself in the Breegus System on Torren IV. From this point on, Alister began gathering information about the Great Clock, hoping it could undo his mistake.
Rebellion and skirmishes with Nefarious
A few decades later Doctor Nefarious rose to power in the Polaris Galaxy. Alister had many confrontations with the doctor and his henchman Lord Vorselon. Despite being captured briefly by Vorselon, Azimuth managed to destroy one of Nefarious's transports, and an outpost in the Korthos Sector belonging to Vorselon.
When Azimuth first met Ratchet, he initially thought that the young Lombax was an assassin wearing a Holo-Guise who had been sent by either Vorselon or Nefarious to kill him. Ratchet chased him, and when he caught up, Azimuth recognized Ratchet as Kaden's son. Azimuth spoke with Ratchet about the Great Clock, and taught Ratchet how to use his father's hoverboots. Afterwards Alister told Ratchet to meet him in Axiom City on planet Terachnos, where they could find a way to talk to Clank in the Great Clock. He and Ratchet infiltrated Pollyx Industries, a company specializing in Zoni technology, and discovered that the last remaining Obsidian Eye in the universe was located in Krell Canyon on Lumos. After battling and defeating a VX-99 sent by Dr. Nefarious they set off for Lumos.
On Lumos, Azimuth explained the story of his exile to Ratchet. He also revealed his plan to gain control of the Great Clock and prevent his actions from leading to the vanishing of the Lombaxes and the death of Ratchet's parents. He promised Ratchet that he would help him get his family back.
Conflict over the Clock
When Ratchet and Clank learned that the Great Clock could rip apart reality if misused, they unsuccessfully attempted to dissuade Azimuth from using it. Azimuth became upset and the general left in his ship. After Ratchet and Clank defeated Dr. Nefarious, Azimuth saved them just before the ship they were standing on collided with the Nefarious Space Station. The three of them flew to the Great Clock where Clank requested to stay to protect the facility. Still intent on using the Clock, Azimuth asked Ratchet about the Lombaxes. Ratchet replied that they'd moved on, but said that the past should not be changed, backing out of Azimuth's plan.
Frustrated and outraged that Ratchet no longer wanted to "save" the Lombaxes, Azimuth furiously shot Ratchet with an energy blast from his wrench, killing him. Azimuth raced Clank to the Orvus Chamber, but the robot managed to seal it off before he could reach it. Inside, thanks to advice given to him by the Plumber, Clank shifted time six minutes into the past and prevented Ratchet from being hit by Azimuth's blast.
Duel in the Orvus Chamber and Death
Pursued by Ratchet and Clank, Azimuth raced to the Orvus Chamber and activated a time shift to prevent the attack on Fastoon. Ratchet then fought him to prevent the destruction of the universe. Upon his defeat, Ratchet told Alister following the effects of the broken lever that the Great Clock wasn't a time machine—it was only meant to keep time and space intact. Realizing his mistake, Alister bid Ratchet a final farewell and used his wrench to move the damaged master switch, reversing the massive wave of quantum energy reverting time back to its normal flow. Though he was successful, the resulting final blast of energy killed Alister. Alister's Praetorian OmniWrench was then taken by Ratchet and put on the wall of his garage along with his other weaponry, and he also kept the pocket watch of his father and Alister.
His death affected Ratchet who felt some guilt over the events.
In Ratchet and Clank: Into the Nexus, in the Lombax History Wing of the Intergalactic Museum of History, there is a statue of him near Ratchet and Clank's, explaining that he has mixed views throughout the galaxy as some see him as a villain who put the entire universe in inter-dimensional danger for his own selfish reasons while others see him as a hero whose only crime was to give Tachyon access to the Lombax Archives, which resulted in the start of Percival's Cragmite Empire and all he wanted is to correct that mistake that he made in the past.
Role in the series
Alister does not appear in the series due to his death, but Ratchet still remembers him as he still keeps his old belongings including his Praetorian Omniwrench. He is mentioned briefly in The Revival of Cronk and Zephyr when Ratchet and his friends in the Anti-Team Nefarious Freedom Fighters realized they were making a mistake similar to what Ratchet and Alister almost did.