As a former athlete, Payne has an expansive knowledge of acrobatics, being able to jump around and flip like a primate, and swing across trees and branches. He can also climb and scale walls very easily. He can scale at any angle, even upside-down. He has an innate jumping height, incredible strength, agility, and stamina, and his roar is ear-shattering. As a lizard, he can naturally regenerate lost limbs and heal from wounds.
He shares the DNA of lions, apes, bears, crocodiles, and even dinosaurs from prehistoric worlds. Though as the result of the warm-blooded and cold-blooded genes being unable to differentiate with each other, Payne's aggression levels are increased which is what caused him to be corrupted upon his mutation. This aggression makes him dangerously difficult to defeat as his adrenaline increases his strength and makes him immune to many forms of pain. His teeth can regenerate due to the dinosaur DNA, the ape DNA increases his agility and his acrobatic capabilities, his crocodile DNA increases his durability and allows him to hold his breath longer underwater, the bear DNA gives him increased strength, and the lion DNA gives him increased agility and a pride-like instinct.
Being exposed to Hank Jr's ingenious machines for so long have allowed him to become an expert mechanic and engineer. Though he still has trouble with mathematical equations and formulas, he is still resourceful enough to eventually become the next mutant mastermind for Poi-Son.